SEEK ID: http://localhost:3000/investigations/3
Projects: SyNergy - published datasets
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Created: 29th May 2024 at 11:36
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Projects: SyNergy - published datasets
Institutions: Klinikum der Universität München
Projects: SyNergy - published datasets
Institutions: Klinikum der Universität München
Public web page: Not specified
Organisms: Mus musculus, Rattus norvegicus, Homo sapiens, Macaca mulatta, Sus scrofa
Mitochondria account for essential cellular pathways, from ATP production to nucleotide metabolism, and their deficits lead to neurological disorders and contribute to the onset of age-related diseases. Direct neuronal reprogramming aims at replacing neurons lost in such conditions, but almost nothing is known about the impact of mitochondrial dysfunction in human cell direct reprogramming. Here we explore the defects and how to improve the neuronal reprogramming of iPSC-derived astrocytes carrying ...
Submitter: Rainer Malik
Investigation: Transcriptomics
Assays: Bulk RNA-seq, scRNA-seq 5 day, scRNA-seq day 20
Snapshots: No snapshots
Submitter: Rainer Malik
Investigation: Transcriptomics
Snapshots: No snapshots
Snapshots: No snapshots
Submitter: Rainer Malik
Investigation: Transcriptomics
Snapshots: No snapshots
Submitter: Rainer Malik
Investigation: Transcriptomics
Snapshots: No snapshots
Submitter: Rainer Malik
Assay type: Transcriptomics
Technology type: Technology Type
Investigation: Transcriptomics
Organisms: No organisms
SOPs: No SOPs
Data files: Histone deacetylase 9 promotes vascular inflamm...
Snapshots: No snapshots
Submitter: Rainer Malik
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: Transcriptomics
Organisms: No organisms
SOPs: No SOPs
Data files: White matter aging drives microglial diversity, White matter aging drives microglial diversity
Snapshots: No snapshots
Submitter: Rainer Malik
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: Transcriptomics
Organisms: No organisms
SOPs: No SOPs
Data files: CD8+ T cells induce interferon-responsive oligo...
Snapshots: No snapshots
Submitter: Rainer Malik
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: Transcriptomics
Organisms: No organisms
SOPs: No SOPs
Data files: Spatial Transcriptomics correlated Electron Mic...
Snapshots: No snapshots
Submitter: Rainer Malik
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: Transcriptomics
Organisms: No organisms
SOPs: No SOPs
Data files: Genetically perturbed myelin as a risk factor f...
Snapshots: No snapshots
Mitochondria account for essential cellular pathways, from ATP production to nucleotide metabolism, and their deficits lead to neurological disorders and contribute to the onset of age-related diseases. Direct neuronal reprogramming aims at replacing neurons lost in such conditions, but almost nothing is known about the impact of mitochondrial dysfunction in human cell direct reprogramming. Here we explore the defects and how to improve the neuronal reprogramming of iPSC-derived astrocytes carrying ...
Creators: Rainer Malik, Magdalena Götz
Submitter: Rainer Malik
Investigations: Transcriptomics
Studies: Direct neuronal reprogramming of NDUFS4 patient...
Assays: scRNA-seq day 20
Mitochondria account for essential cellular pathways, from ATP production to nucleotide metabolism, and their deficits lead to neurological disorders and contribute to the onset of age-related diseases. Direct neuronal reprogramming aims at replacing neurons lost in such conditions, but almost nothing is known about the impact of mitochondrial dysfunction in human cell direct reprogramming. Here we explore the defects and how to improve the neuronal reprogramming of iPSC-derived astrocytes carrying ...
Creators: Rainer Malik, Magdalena Götz
Submitter: Rainer Malik
Investigations: Transcriptomics
Studies: Direct neuronal reprogramming of NDUFS4 patient...
Assays: scRNA-seq 5 day
Mitochondria account for essential cellular pathways, from ATP production to nucleotide metabolism, and their deficits lead to neurological disorders and contribute to the onset of age-related diseases. Direct neuronal reprogramming aims at replacing neurons lost in such conditions, but almost nothing is known about the impact of mitochondrial dysfunction in human cell direct reprogramming. Here we explore the defects and how to improve the neuronal reprogramming of iPSC-derived astrocytes carrying ...
Creators: Rainer Malik, Magdalena Götz
Submitter: Rainer Malik
Investigations: Transcriptomics
Studies: Direct neuronal reprogramming of NDUFS4 patient...
Assays: Bulk RNA-seq
The crosstalk between brain infiltrating T cells and microglia in response to stroke remains elusive. Benakis et al. report that transcriptional signature of the stroke-associated microglia is reprogrammed by distinct T cell subpopulations. Engineered T cells overexpressing IL-10 administered four hours after stroke reinitiate microglial transcriptomic profile inducing a pro-regenerative environment.
Creator: Arthur Liesz
Submitter: Rainer Malik
Investigations: Transcriptomics
Cortical pathology contributes to chronic cognitive impairment of patients suffering from the neuroinflammatory disease multiple sclerosis (MS). How such gray matter inflammation affects neuronal structure and function is not well understood. Here we use functional and structural in vivo imaging in a mouse model of cortical MS to demonstrate that bouts of cortical inflammation disrupt cortical circuit activity coincident with a widespread, but transient loss of dendritic spines. Spines destined ...
Creator: Rainer Malik
Submitter: Rainer Malik
Investigations: Transcriptomics