Expression profiling by high throughput sequencing
SEEK ID: http://localhost:3000/assays/8
Experimental assay
Projects: SyNergy - published datasets
Investigation: Transcriptomics
Study: Myelin degeneration in leucodystrophies
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Assay type: Experimental Assay Type
Technology type: Technology Type
Organisms: No organisms
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Creators and SubmitterViews: 13
Created: 27th Jun 2024 at 12:06
Last updated: 27th Jun 2024 at 12:07
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Projects: SyNergy - published datasets
Institutions: Klinikum der Universität München
Public web page: Not specified
Submitter: Rainer Malik
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Submitter: Rainer Malik
Investigation: Transcriptomics
Axon degeneration and neurological dysfunction in myelin diseases is often attributed to loss of myelin. Perturbed myelinating glia can instigate chronic neuroinflammation and contribute to demyelination and axonal damage. We have previously shown in mice that distinct defects in the proteolipid protein 1 gene result in axonal damage which is largely driven by cytotoxic T cells targeting myelinating oligodendrocytes. Here we show in these mutants that persistent ensheathment with perturbed myelin ...
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