SEEK ID: http://localhost:3000/people/3
Location: Germany
ORCID: Not specified
Joined: 29th May 2024
Expertise: Not specified
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- Projects (1)
- Institutions (1)
- Investigations (1)
- Studies (3)
- Assays (1)
- Data files (2)
- Publications (2)
Public web page: Not specified
Organisms: Mus musculus, Rattus norvegicus, Homo sapiens, Macaca mulatta, Sus scrofa
Submitter: Rainer Malik
Studies: A genome-wide in vivo CRISPR screen identifies essential regulators of T..., Correlation spatial transcriptomics/EM, Direct neuronal reprogramming of NDUFS4 patient cells identifies the unf..., Early adaptive immune activation detected in monozygotic twins with prod..., Histone Deacetylase 9 Activates IKK to Regulate Atherosclerotic Plaque V..., Innate immune memory after brain injury drives inflammatory cardiac dysf..., Microglia in white matter aging, Myelin degeneration in leucodystrophies, Oligodendrocytes in AD models, Oligodendrocytes in white matter aging, Phagocyte-mediated synapse removal in cortical neuroinflammation is prom..., Skin and gut imprinted helper T cell subsets exhibit distinct functional..., T cells modulate the microglial response to brain ischemia
Assays: Bulk RNA-seq, Expression profiling by high throughput sequencing, Expression profiling by high throughput sequencing, Expression profiling by high throughput sequencing, Expression profiling by high throughput sequencing, Expression profiling by high throughput sequencing, Expression profiling by high throughput sequencing, Expression profiling by high throughput sequencing, Expression profiling by high throughput sequencing, Expression profiling by high throughput sequencing, Expression profiling by high throughput sequencing, Single cell RNA sequencing experiment, scRNA-seq 5 day, scRNA-seq day 20
Snapshots: No snapshots
Cerebral amyloid angiopathy (CAA) is an age-related condition and a major cause of intracerebral hemorrhage and cognitive decline that shows close links with Alzheimer's disease (AD). CAA is characterized by the aggregation of amyloid-β (Aβ) peptides and formation of Aβ deposits in the brain vasculature resulting in a disruption of the angioarchitecture. Capillaries are a critical site of Aβ pathology in CAA type 1 and become dysfunctional during disease progression. Here, applying an advanced ...
Snapshots: No snapshots
Age-related decline in brain endothelial cell (BEC) function critically contributes to cerebrovascular and neurodegenerative disease. Comprehensive atlases of the BEC transcriptome have become available but results from proteomic profiling are lacking. To gain insights into endothelial pathways affected by aging, we developed a magnetic-activated cell sorting (MACS)-based mouse BEC enrichment protocol compatible with high-resolution mass-spectrometry and analysed the profiles of protein abundance ...
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Comparison of TNFα activated BMDM from B6.129P2-Apoetm1Unc/J mice treated with the inhibitors TMP195 or TPCA-1.
Submitter: Rainer Malik
Investigation: Transcriptomics
Snapshots: No snapshots
Submitter: Rainer Malik
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: Proteomics
Organisms: Homo sapiens
SOPs: No SOPs
Data files: Proteome analysis of microvessels from CAA and ...
Snapshots: No snapshots
Cerebral amyloid angiopathy (CAA) is an age-related condition and a major cause of intracerebral hemorrhage and cognitive decline that shows close links with Alzheimer's disease (AD). CAA is characterized by the aggregation of amyloid-β (Aβ) peptides and formation of Aβ deposits in the brain vasculature resulting in a disruption of the angioarchitecture. Capillaries are a critical site of Aβ pathology in CAA type 1 and become dysfunctional during disease progression. Here, applying an advanced ...
Creators: Rainer Malik, Stefan Lichtenthaler, Stephan Müller, Martin Dichgans
Submitter: Rainer Malik
Investigations: Proteomics
Studies: Proteomic profiling in cerebral amyloid angiopa...
Assays: Shotgun proteomics
Creators: Rainer Malik, Martin Dichgans
Submitter: Rainer Malik
Investigations: Transcriptomics
Abstract (Expand)
Authors: K. Todorov-Volgyi, J. Gonzalez-Gallego, S. A. Muller, N. Beaufort, R. Malik, M. Schifferer, M. I. Todorov, D. Crusius, S. Robinson, A. Schmidt, J. Korbelin, F. Bareyre, A. Erturk, C. Haass, M. Simons, D. Paquet, S. F. Lichtenthaler, M. Dichgans
Date Published: 22nd Apr 2024
Publication Type: Journal
PubMed ID: 38519806
Citation: Nat Aging. 2024 Apr;4(4):595-612. doi: 10.1038/s43587-024-00598-z. Epub 2024 Mar 22.
Abstract (Expand)
Authors: A. Zellner, S. A. Muller, B. Lindner, N. Beaufort, A. J. M. Rozemuller, T. Arzberger, N. C. Gassen, S. F. Lichtenthaler, B. Kuster, C. Haffner, M. Dichgans
Date Published: 24th Jan 2022
Publication Type: Journal
PubMed ID: 35074002
Citation: Acta Neuropathol Commun. 2022 Jan 24;10(1):6. doi: 10.1186/s40478-021-01303-6.