Expression profiling: Bulk RNA-seq (mouse)
SEEK ID: http://lmmeisd-2.srv.mwn.de/assays/3
Experimental assay
Projects: Published Datasets
Investigation: Transcriptomics (Published)
Study: Histone Deacetylase 9 Activates IKK to Regulate Atherosclerotic Plaque Vulnerability
Assay position:
Assay type: Transcriptomics
Technology type: Sequencing
Organisms: Mus musculus
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Creators and SubmitterViews: 60
Created: 29th May 2024 at 11:38
Last updated: 11th Oct 2024 at 13:16
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Projects: Published Datasets, Unpublished Datasets
Institutions: LMU Klinikum
Research Data Steward
This project serves as a centralized repository for omics datasets published by research groups within the SyNergy Cluster. It encompasses investigations such as proteomics and transcriptomics, which are further divided into individual studies led by SyNergy members. Each study is linked to relevant publications, assays and data files (with links to external repositories).
To explore investigations and their associated studies in more detail, please visit the 'Related items' tab on the Project ...
Public web page: Not specified
Submitter: Rainer Malik
Studies: A genome-wide in vivo CRISPR screen identifies essential regulators of T..., Adult neural stem cell activation in mice is regulated by the day/night ..., Diet triggers specific responses of hypothalamic astrocytes in time and ..., Direct neuronal reprogramming of NDUFS4 patient cells identifies the unf..., Distinct molecular profiles of skull bone marrow in health and neurologi..., Early adaptive immune activation detected in monozygotic twins with prod..., Heterogeneity of neurons reprogrammed from spinal cord astrocytes by the..., High-calorie diets uncouple hypothalamic oxytocin neurons from a gut-to-..., Histone Deacetylase 9 Activates IKK to Regulate Atherosclerotic Plaque V..., Innate Immune Pathways Promote Oligodendrocyte Progenitor Cell Recruitme..., Innate immune memory after brain injury drives inflammatory cardiac dysf..., MicroRNAs from extracellular vesicles as a signature for Parkinson's dis..., Microglia in white matter aging, Molecular diversity of diencephalic astrocytes reveals adult astrogenesi..., Multiomic ALS signatures highlight subclusters and sex differences sugge..., Multi‐omic landscaping of human midbrains identifies disease‐relevant mo..., Myelin degeneration in leucodystrophies, Oligodendrocytes in AD models, Oligodendrocytes in white matter aging, Parkinson's disease motor symptoms rescue by CRISPRa‐reprogramming astro..., Peripheral expression of brain-penetrant progranulin rescues pathologies..., Phagocyte-mediated synapse removal in cortical neuroinflammation is prom..., Shared inflammatory glial cell signature after stab wound injury, reveal..., Skin and gut imprinted helper T cell subsets exhibit distinct functional..., Spatial Transcriptomics-correlated Electron Microscopy maps transcriptio..., Spatial centrosome proteome of human neural cells uncovers disease-relev..., T cells modulate the microglial response to brain ischemia, Twin study identifies early immunological and metabolic dysregulation of...
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Rationale: Arterial inflammation manifested as atherosclerosis is the leading cause of mortality worldwide. Genome-wide association studies have identified a prominent role of HDAC (histone deacetylase)-9 in atherosclerosis and its clinical complications including stroke and myocardial infarction.
Objective: To determine the mechanisms linking HDAC9 to these vascular pathologies and explore its therapeutic potential for atheroprotection.
Methods and Results: We studied the effects of Hdac9 on ...
Submitter: Rainer Malik
Investigation: Transcriptomics (Published)
Comparison of TNFα activated BMDM from B6.129P2-Apoetm1Unc/J mice treated with the inhibitors TMP195 or TPCA-1. Cells were treated for 1h with the respective inhibitors, followed by 24h stimulation with TNFα and subsequently lysed in Trizol.
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