Matthias Tschöp
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SEEK ID: http://lmmeisd-2.srv.mwn.de/people/26
Location:
Germany
ORCID: Not specified
Joined: 18th Dec 2024
Expertise: Not specified
Tools: Not specified
Their tagsRelated items
This project serves as a centralized repository for omics datasets published by research groups within the SyNergy Cluster. It encompasses investigations such as proteomics and transcriptomics, which are further divided into individual studies led by SyNergy members. Each study is linked to relevant publications, assays and data files (with links to external repositories).
To explore investigations and their associated studies in more detail, please visit the 'Related items' tab on the Project ...
Public web page: Not specified
This project serves as a centralized repository for unpublished omics datasets from ongoing research led by SyNergy group leaders. It includes sample metadata and assay information for studies currently in progress, grouped under investigations such as proteomics and transcriptomics. The project aims to facilitate collaboration and data management within the cluster while maintaining confidentiality for unpublished work.
To explore investigations and their associated studies in more detail, please ...
Public web page: Not specified
Oxytocin-expressing paraventricular hypothalamic neurons (PVNOT neurons) integrate afferent signals from the gut, including cholecystokinin (CCK), to adjust whole-body energy homeostasis. However, the molecular underpinnings by which PVNOT neurons orchestrate gut-to-brain feeding control remain unclear. Here, we show that mice undergoing selective ablation of PVNOT neurons fail to reduce food intake in response to CCK and develop hyperphagic obesity on a chow diet. Notably, exposing wild-type ...
Submitter: Aditi Methi
Investigation: Transcriptomics (Published)
Assays: Expression profiling: RiboTag-mRNA-seq (mouse), Expression profiling: scRNA-seq (mouse)
Hypothalamic astrocytes are particularly affected by energy-dense food consumption. How the anatomical location of these glial cells and their spatial molecular distribution in the arcuate nucleus of the hypothalamus (ARC) determine the cellular response to a high caloric diet remains unclear. In this study, we investigated their distinctive molecular responses following exposure to a high-fat high-sugar (HFHS) diet, specifically in the ARC. Using RNA sequencing and proteomics, we showed that ...
Submitter: Aditi Methi
Investigation: Transcriptomics (Published)
Assays: Expression profiling: Bulk RNA-seq (mouse), Expression profiling: scRNA-seq (mouse)
Abstract (Expand)
Authors: Tim Gruber, Franziska Lechner, Cahuê Murat, Raian E Contreras, Eva Sanchez-Quant, Viktorian Miok, Konstantinos Makris, Ophélia Le Thuc, Ismael González-García, Elena García-Clave, Ferdinand Althammer, Quirin Krabichler, Lisa M DeCamp, Russell G Jones, Dominik Lutter, Rhiannan H Williams, Paul T Pfluger, Timo D Müller, Stephen C Woods, John Andrew Pospisilik, Celia P Martinez-Jimenez, Matthias H Tschöp, Valery Grinevich, Cristina Garcia-Caceres
Date Published: 31st Oct 2023
Publication Type: Journal
Abstract (Expand)
Authors: Luiza Maria Lutomska, Viktorian Miok, Natalie Krahmer, Ismael González García, Tim Gruber, Ophélia Le Thuc, Cahuê Db Murat, Beata Legutko, Michael Sterr, Gesine Saher, Heiko Lickert, Timo D Müller, Siegfried Ussar, Matthias H Tschöp, Dominik Lutter, Cristina Garcia-Caceres
Date Published: 8th Jul 2022
Publication Type: Journal
