Expression profiling: scRNA-seq (mouse)
SEEK ID: http://lmmeisd-2.srv.mwn.de/assays/82
Experimental assay
Projects: Published Datasets
Investigation: Transcriptomics (Published)
Study: Molecular diversity of diencephalic astrocytes reveals adult astrogenesis regulated by Smad4
Assay position:
Assay type: Transcriptomics
Technology type: Sequencing
Organisms: Mus musculus
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Creators and SubmitterViews: 41
Created: 14th Oct 2024 at 13:39
Last updated: 14th Oct 2024 at 15:46
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Projects: Published Datasets, Unpublished Datasets
Institutions: LMU Klinikum
Research Data Manager
This project serves as a centralized repository for omics datasets published by research groups within the SyNergy Cluster. It encompasses investigations such as proteomics and transcriptomics, which are further divided into individual studies led by SyNergy members. Each study is linked to relevant publications, assays and data files (with links to external repositories).
To explore investigations and their associated studies in more detail, please visit the 'Related items' tab on the Project ...
Public web page: Not specified
Submitter: Rainer Malik
Studies: A genome-wide in vivo CRISPR screen identifies essential regulators of T..., Adult neural stem cell activation in mice is regulated by the day/night ..., Diet triggers specific responses of hypothalamic astrocytes in time and ..., Direct neuronal reprogramming of NDUFS4 patient cells identifies the unf..., Distinct molecular profiles of skull bone marrow in health and neurologi..., Early adaptive immune activation detected in monozygotic twins with prod..., Heterogeneity of neurons reprogrammed from spinal cord astrocytes by the..., High-calorie diets uncouple hypothalamic oxytocin neurons from a gut-to-..., Histone Deacetylase 9 Activates IKK to Regulate Atherosclerotic Plaque V..., Innate Immune Pathways Promote Oligodendrocyte Progenitor Cell Recruitme..., Innate immune memory after brain injury drives inflammatory cardiac dysf..., MicroRNAs from extracellular vesicles as a signature for Parkinson's dis..., Microglia in white matter aging, Molecular diversity of diencephalic astrocytes reveals adult astrogenesi..., Multiomic ALS signatures highlight subclusters and sex differences sugge..., Multi‐omic landscaping of human midbrains identifies disease‐relevant mo..., Myelin degeneration in leucodystrophies, Oligodendrocytes in AD models, Oligodendrocytes in white matter aging, Parkinson's disease motor symptoms rescue by CRISPRa‐reprogramming astro..., Peripheral expression of brain-penetrant progranulin rescues pathologies..., Phagocyte-mediated synapse removal in cortical neuroinflammation is prom..., Shared inflammatory glial cell signature after stab wound injury, reveal..., Skin and gut imprinted helper T cell subsets exhibit distinct functional..., Spatial Transcriptomics-correlated Electron Microscopy maps transcriptio..., Spatial centrosome proteome of human neural cells uncovers disease-relev..., T cells modulate the microglial response to brain ischemia, Twin study identifies early immunological and metabolic dysregulation of...
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Astrocytes regulate brain‐wide functions and also show region‐specific differences, but little is known about how general and region‐specific functions are aligned at the single‐cell level. To explore this, we isolated adult mouse diencephalic astrocytes by ACSA‐2‐mediated magnetic‐activated cell sorting (MACS). Single‐cell RNA‐seq revealed 7 gene expression clusters of astrocytes, with 4 forming a supercluster. Within the supercluster, cells differed by gene expression related to ion homeostasis ...
Submitter: Aditi Methi
Investigation: Transcriptomics (Published)
Assays: Expression profiling: Bulk RNA-seq (mouse), Expression profiling: scRNA-seq (mouse)
Diencephalic astrocytes from 3 months old Aldh1l1-eGFP mice were ACSA2 MACS sorted and processed using Single Cell Reagent Kits V2 from 10x Genomics (scRNA-seq).
External LinkDiencephalic astrocytes from 3 months old Aldh1l1-eGFP mice were ACSA2 MACS sorted and processed using Single Cell 3’ Reagent Kits V2 from 10x Genomics (scRNA-seq).
