Expression profiling by high throughput sequencing
SEEK ID: http://localhost:3000/assays/11
Experimental assay
Projects: SyNergy - published datasets
Investigation: Transcriptomics
Study: Early adaptive immune activation detected in monozygotic twins with prodromal multiple sclerosis
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Assay type: Experimental Assay Type
Technology type: Technology Type
Organisms: No organisms
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Creators and SubmitterViews: 18
Created: 28th Jun 2024 at 08:45
Last updated: 28th Jun 2024 at 08:46
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Projects: SyNergy - published datasets
Institutions: Klinikum der Universität München
Public web page: Not specified
Submitter: Rainer Malik
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Submitter: Rainer Malik
Investigation: Transcriptomics
Here we investigated the earliest possible evidence of subclinical neuro-inflammation (SCNI) using a small cohort of monozygotic twins where one sibling had clinically definite MS and the other been clinically "healthy" but has a maximal genetic for developing MS. In contrast to subjects with radiologically isolated syndrome (RIS), our group of very early SCNI does not even fulfill the (arbitrary) MRI criteria for RIS but have more subtle MRI changes and/or evidence of neuro-inflammation in the ...
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