Expression profiling: Bulk RNA-seq (mouse)
Comparative gene expression profiling analysis of RNA-seq data for four transgenic mouse models ( C9orf72, SOD1, TDP-43 and FUS) of ALS with each 5 males/females and 5 case/control samples. For FUS one male control sample was excluded.
SEEK ID: http://localhost:3000/assays/104
Experimental assay
Projects: SyNergy - Published Datasets
Investigation: Transcriptomics
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Assay type: Transcriptomics
Technology type: Sequencing
Organisms: Mus musculus
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Created: 25th Oct 2024 at 09:35
Last updated: 25th Oct 2024 at 09:36
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Projects: SyNergy - Published Datasets
Institutions: Klinikum der Universität München
Public web page: Not specified
Submitter: Rainer Malik
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Amyotrophic lateral sclerosis (ALS) is a debilitating motor neuron disease and lacks effective disease-modifying treatments. This study utilizes a comprehensive multiomic approach to investigate the early and sex-specific molecular mechanisms underlying ALS. By analyzing the prefrontal cortex of 51 patients with sporadic ALS and 50 control subjects, alongside four transgenic mouse models (C9orf72-, SOD1-, TDP-43-, and FUS-ALS), we have uncovered significant molecular alterations associated with ...
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