To study the regulation of candidate genes from our study in human cells, we analyzed CD4+ T cells from blood and CSF of MA patients and age and sex matched idiopathic intracranial hypertension controls
We analyzed 40845 cells in control blood, 807 cells in control CSF, 29749 cells in MS blood and 15768 cells in MS CSF
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Created: 28th Jun 2024 at 08:41
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Version 1 (earliest) Created 28th Jun 2024 at 08:41 by Rainer Malik
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Projects: SyNergy - published datasets
Institutions: Klinikum der Universität München
Public web page: Not specified
Organisms: Mus musculus, Rattus norvegicus, Homo sapiens, Macaca mulatta, Sus scrofa
Submitter: Rainer Malik
Studies: A genome-wide in vivo CRISPR screen identifies essential regulators of T..., Correlation spatial transcriptomics/EM, Direct neuronal reprogramming of NDUFS4 patient cells identifies the unf..., Early adaptive immune activation detected in monozygotic twins with prod..., Histone Deacetylase 9 Activates IKK to Regulate Atherosclerotic Plaque V..., Innate immune memory after brain injury drives inflammatory cardiac dysf..., Microglia in white matter aging, Myelin degeneration in leucodystrophies, Oligodendrocytes in AD models, Oligodendrocytes in white matter aging, Phagocyte-mediated synapse removal in cortical neuroinflammation is prom..., Skin and gut imprinted helper T cell subsets exhibit distinct functional..., T cells modulate the microglial response to brain ischemia
Assays: Bulk RNA-seq, Expression profiling by high throughput sequencing, Expression profiling by high throughput sequencing, Expression profiling by high throughput sequencing, Expression profiling by high throughput sequencing, Expression profiling by high throughput sequencing, Expression profiling by high throughput sequencing, Expression profiling by high throughput sequencing, Expression profiling by high throughput sequencing, Expression profiling by high throughput sequencing, Expression profiling by high throughput sequencing, Single cell RNA sequencing experiment, scRNA-seq 5 day, scRNA-seq day 20
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Submitter: Rainer Malik
Investigation: Transcriptomics
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Submitter: Rainer Malik
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: Transcriptomics
Organisms: No organisms
SOPs: No SOPs
Data files: Effect of Grk2 (spleen, rat) or Ets1 (spleen an..., Genome wide (GW) and validation CRISPR screens ..., scRNAseq of blood and CSF CD4+ T cells from MS ...
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Abstract (Expand)
Authors: A. Kendirli, C. de la Rosa, K. F. Lammle, K. Eglseer, I. J. Bauer, V. Kavaka, S. Winklmeier, L. Zhuo, C. Wichmann, L. A. Gerdes, T. Kumpfel, K. Dornmair, E. Beltran, M. Kerschensteiner, N. Kawakami
Date Published: 4th Oct 2023
Publication Type: Journal
PubMed ID: 37709997
Citation: Nat Neurosci. 2023 Oct;26(10):1713-1725. doi: 10.1038/s41593-023-01432-2. Epub 2023 Sep 14.