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Rainer Malik1
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Christian Behrends1
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AMPK is a central regulator of metabolism and autophagy. Here we show how lysosomal damage activates AMPK. This occurs via a hitherto unrecognized signal transduction system whereby cytoplasmic sentinel lectins detect membrane damage leading to ubiquitination responses. Absence of Galectin 9 (Gal9) or loss of its capacity to recognize lumenal glycans exposed during lysosomal membrane damage abrogate such ubiquitination responses. Proteomic analyses with APEX2-Gal9 have revealed global changes ...
Submitter: Rainer Malik
Investigation: Proteomics (Published)
Assays: Affinity purification coupled with mass spectrometry proteomics (human)