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Rainer Malik1
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SyNergy - published datasets1
Creator
Rainer Malik1
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Experimental Assay Type1
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A hallmark of nervous system aging is a decline of white matter volume and function, but the underlying mechanisms leading to white matter pathology are unknown. Here, we found age-related alterations of oligodendrocytes with a reduction of total oligodendrocyte density in the aging murine white matter. Using single-cell RNA sequencing, we identify interferon-responsive oligodendrocytes, which localize in proximity of CD8+ T cells in the aging white matter. Absence of functional lymphocytes ...
Creator: Rainer Malik
Submitter: Rainer Malik