Data files
What is a Data file?Filters
Query
Created At
Updated At
Submitter
Rainer Malik1
Project
Published Datasets1
Creator
Rainer Malik1
Assay type
Proteomics1
Technology type
Technology Type1
1
Data file visible to you, out of a total of 1
The protease BACE1 is a major drug target for Alzheimer’s disease, but chronic BACE1 inhibition is associated with non-progressive worsening that may be caused by modulation of unknown physiological BACE1 substrates. To identify in vivo-relevant BACE1 substrates we applied pharmacoproteomics to non-human-primate cerebrospinal fluid (CSF) after acute treatment with BACE inhibitors. Besides SEZ6, the strongest, dose-dependent reduction was observed for the pro-inflammatory cytokine receptor ...
Creator: Rainer Malik
Submitter: Rainer Malik